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College football fans will turn their attention to the Pacific Northwest this weekend for a pair of rivalry games during the Week 3 college football schedule. No. 9 Oregon travels to Oregon State on Saturday, with the Ducks listed as 16.5-point favorites in the Week 3 college football odds.

Meanwhile, Washington is a 4.5-point home favorite against Washington State in the Apple Cup. There are several other rivalry games taking place this weekend, including No. 12 Utah vs. Utah State and Purdue vs. No. 18 Notre Dame.

Top-ranked Georgia (-24.5 at Kentucky) and No. 4 Alabama (-16.5 at Wisconsin) will both be looking to make statements by covering their respective Week 3 college football spreads on the road. Should you back either of those favorites with your Week 3 college football bets? Before locking in any Week 3 college football picks on those games or others, be sure to see the latest college football predictions from SportsLine's proven model.

The model simulates every FBS college football game 10,000 times. Since its inception, it has generated a profit of over $2,000 for $100 players on its top-rated college football picks against the spread. It is also coming off a profitable 13-9 season on top-rated spread picks and is off to a 4-0 start on over/under picks this season. Anyone who has followed it has seen strong returns!

Now, it has turned its attention to the latest college football odds and Week 3 college football betting lines on the spread, money line, and over/under. Head here to see every pick.

Top college football predictions for Week 3

One of the college football picks the model is high on during Week 3: Washington (-4.5) covers in its Apple Cup rivalry game at Washington State in a 3:30 p.m. ET on Saturday. The Apple Cup has been one-sided over the past decade, as Washington is 9-1 straight up and 7-3 against the spread in the last 10 meetings. The Huskies are playing under a new coaching staff following their run to the national championship game last season, but they are off to a strong start with blowout wins over Weber State and Eastern Michigan.

Transfer quarterback Will Rogers has already racked up 511 passing yards and five touchdowns, while transfer running back Jonah Coleman has rushed for 231 yards and three scores. They are facing a Washington State defense that allowed 30 points to FCS Portland State in Week 1, and the Cougars are going on the road for the first time this season. Washington has consistently been the better team in this rivalry, and the model has the Huskies covering the spread in well over 60% of simulations. See the rest of its Week 3 college football picks here.

Another prediction: No. 5 Ole Miss (-22.5) covers the huge spread at Wake Forest in a 6:30 p.m. ET kickoff on Saturday. The Demon Deacons are off to a rough start this season, allowing Virginia to erase a 30-17 deficit in a 31-30 final last week. Their defense is allowing 383.5 yards per game, which does not bode well as they get set to face one of the best offenses in college football.

Ole Miss has outscored its first two opponents 128-3, covering the spread as a heavy favorite in both of those games. Senior quarterback Jaxson Dart has thrown for 795 yards and six touchdowns, completing 87% of his 54 pass attempts. The Rebels have covered the spread in five of their last six games against ACC opponents, and SportsLine's model has them covering in almost 60% of its latest simulations. See picks for every other game in Week 3 here.

How to make college football picks for Week 3

The model has also made the call on who wins and covers in every FBS matchup in Week 3, and it's calling for an underdog to win outright in a primetime game. You can only get every pick for every game at SportsLine.

So what college football picks can you make with confidence, and which underdog wins outright in one of the biggest games in Week 3? Check out the latest college football odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned over $2,000 in profit since its inception, and find out.

College football odds for Week 3

See full Week 3 college football picks, odds, predictions here

Thursday, Sept. 12

Arizona State at Texas State (-2.5, 59.5)

Friday, Sept. 13

UNLV at Kansas (-7, 58)

Arizona at Kansas State (-7.5, 59.5)

Saturday, Sept. 14

LSU at South Carolina (+6.5, 49.5)

Alabama at Wisconsin (+16.5, 49.5)

Boston College at Missouri (-16.5, 54)

Texas A&M at Florida (+3.5, 47)

Tulane at Oklahoma (-13.5, 47.5)

Oregon at Oregon State (+16.5, 51)

Washington State at Washington (-4.5, 56.5)

Notre Dame at Purdue (+10, 45.5)

Georgia at Kentucky (+24.5, 45.5)

Colorado at Colorado State (+7, 58.5)

Indiana at UCLA (+3, 46)